A novel system for the indirect calorimetry of mice, rats, birds, and other small animals. Simply connect the CaloBox with an animal cuvette, turn on air flow, and press “Start” for a measurement.
Common applications are: Animal metabolism, nutrition, heat regulation, thermoregulation, bioenergetics, activity, animal behavior, energy balance, resting metabolic rate, energetics of locomotion, and many more.
The Calobox automtically measures and calculates typical indirect calorimetry parameters such as metabolic rate, energy expenditure (EE), and respiratory exchange ratio (RER). Video introduction.
Developed by Prof. Dr. Gerhard Heldmaier, Philipps-Universität Marburg, Germany.
The PhenoSys CaloBox is a PhenoSys Collaboration product. These products are brought to market together with the scientists who developed them. The CaloBox is a joint product of Prof. Dr. Gerhard Heldmaier and PhenoSys.
Calculation of metabolic rates:
Calculates energy expenditure (EE) based on V′O2 and RER
Check out the Wikipedia page for a basic introduction into the topic.
|Dimensions||35 x 30 x 15.8 cm|
|Mass flowmeter for sample air / Response time / Repeatability||0...5 sLpm (0….300 L/h) / 60 msec / +- 0.5%|
|Electrochemical O2-cell. Range / response time / accuracy||0….25 Vol% / 12 sec / <1% @ 21 Vol%|
|CO2 measurement, NDIR-cell (non dispersive infrared): range / response time / accuracy||0...0.5 Vol% / 20sec / +-30 ppm|
|HT-Sensor, relative humidity resolution / temperature sensor resolution||0.025% / 0.04°C|
|Thermocouple Type T, Cu-Const, resolution||+/- 0.1 °C|
|Membrane pumps||longlife with brushless dc motor|
CaloBox with small animal cuvette
Martire, V. L., Berteotti, C., Bastianini, S., Alvente, S., Valli, A., Cerri, M., … & Zoccoli, G. (2020). The physiological signature of daily torpor is not orexin dependent. J Comp Physiol B.; 190(4):493-507.
Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., … & Astiz, M. (2019). Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption. Cell reports, 27(11), 3385-3400.