Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Brain-resident macrophages, microglia, have been proposed to have an active role in synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here we show that several neurodevelopmental processes previously attributed to microglia…
Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging
The progressive loss of cerebral white matter during aging contributes to cognitive decline, but whether reduced blood flow is a cause or a consequence remains debatable. Using deep multi-photon imaging in mice,…
Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration
Restoring retinal pigment epithelium (RPE) cells is crucial for treating retinal degenerative (RD) diseases, with chemical reprogramming offering a transformative, scalable solution. However, identifying key chemical compounds for generating functional RPE cells…
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome
ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB…
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Brain-resident macrophages, microglia, have been proposed to have an active role in synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here we show that several neurodevelopmental processes previously attributed to microglia…
Spatially heterogeneous acetylcholine dynamics in the striatum promote behavioral flexibility
Being able to switch from established choices to new alternatives when conditions change – behavioral flexibility – is essential for survival. Cholinergic signaling in the striatum contributes to such flexible behavior, yet…