Bridging Neural Dynamics and Natural Behavior
The Mini2P is a groundbreaking miniature two-photon microscope that redefines in vivo brain imaging. Weighing less than 3 grams, it is the lightest model on the market and features integrated on-scope SiPM detectors. This design enables stable, high-resolution recordings from thousands of neurons across multiple brain regions—all while animals move freely and behave naturally.
Offered as a turnkey solution, the scope comes with the Mini2P Hub — a compact, mobile workstation (H 0.8 m × W 0.6 m × D 1.0 m) that hosts all necessary hardware and software, requiring only a single power connection.
Features
Ultra-light microscope body (approx. 2.6 g) with MEMS scanner for X-Y-scanning and µTlens for Z-scanning.
Two photon laser (920nm) with clean femtosecond pulses (<120 fs).
Light and flexible fibers and wires, with over of 2.2 m length allowing maximum freedom for the animal to move.
Huge vDAQ board for synchronization of all desired peripheral devices
Powerful workstation with all required hardware and software pre-installed.
Compact hardware design, everything integrated on a mobile trolley.
Key Benefits
Imaging on the Move
Miniature & Lightweight Microscope Body: Designed to be head mounted allowing mice to move freely.
Fast & High-Resolution: Capture rapid neural dynamics with exceptional cellular detail across multiple focal planes.
Stable Simultaneous Recordings: Acquire reliable data from thousands of neurons concurrently, even during dynamic behaviors like climbing and jumping.
Versatile Imaging Capabilities
Multi-Layer Imaging: Image neuronal activity across different layers or depths within a region.
Access to Diverse Brain Regions: Capable of imaging critical areas like the visual cortex, hippocampus, and other regions of interest.
Data Integration: Designed to facilitate easy combination of imaging data with other peripheral devices
Comprehensive Support & Expertise
Expert System Mastery: Our specialists provide end-to-end expertise and deep system knowledge for efficient troubleshooting and hands-on guidance, ensuring the highest level of assistance.
Onboarding & 24-Hour Response: Get a ready-to-use system with on-site training. We guarantee reliable support and a rapid 24-hour response, available online and on-site.
Commitment to Future-Proofing
Modular Design: The modular design guarantees ease of integration and facilitates future upgrades.
Continuous Innovation: Continuously innovated for expanding applications like FLIM imaging and Multi-Mini2P.
Ready-to-Use System: 
Full Installation Support: Applications
The Mini2P system is a powerful tool for researchers investigating fundamental questions in brain research.
Neural Circuit Function
Study the neurons during cognitive tasks, sensory processing, and motor control.
Learning & Memory
Investigate the cellular mechanisms underlying memory formation, consolidation, and retrieval in behaving animals.
Sensory Processing
Analyze how sensory information (e.g., visual, auditory, somatosensory) is processed and integrated in real-time.
Neurological Disorders
Characterize neural circuit dysfunction in animal models of neurological and psychiatric diseases.
Brain-Wide Activity Mapping
Explore coordinated activity patterns across different brain layers during complex behaviors.
Publications
Large-scale two-photon calcium imaging in freely moving mice
Journal: Cell, Volume 185, Issue 7, Pages 1240-1256.e30
DOI: 10.1016/j.cell.2022.02.017
Frequently Asked Questions
Interoperability, Customization & Modularity
Can the system be customized to fit specific experimental needs?
Yes
Installation and set-up
How long does setup take?
1 Day
Is on-site or remote support available?
Yes, full on-site support including installation, training on Mini2P is provided. Remote support/aftercare is also available
What are the space & power requirements?
Required free space: ~1.5 m x 2 m for rack. AC in room.
Data Collection, Storage & Security
How is data collected, stored, and exported?-
Data is collected and saved as .tiff. 1Tb SSD for recording, 18Tb HDD for storage comes with the system. Integration with network/server is also possible.
User Experience
Yes
Technical Support & Troubleshooting
What are the channels which can be used to reach for technical support?
https://www.phenosys.com/tech-support-form/
Warranty & Service Terms
What’s the warranty period?
1 Year
What does it cover?
details @Marekting/Sales
Are extended service plans available?
yes, details @Marekting/Sales
Have Questions?
Contact Us
Get in touch with us and let us know how we can assist you.