One-third of the risk for Alzheimer’s disease is explained by environment and lifestyle, but Alzheimer’s disease pathology might also affect lifestyle and thereby impair the individual potential for health behavior and prevention.

We examined in mice how the App^NL-F/NL-F (NL-F) knockin mutation affects the presymptomatic response to environmental enrichment (ENR) as an experimental paradigm addressing nongenetic factors. We assessed the emergence of interindividual phenotypic variation under the condition that both the genetic background and the shared environment were held constant, thereby isolating the contribution of individual behavior (nonshared environment).